[Network pharmacological study of Schizonepetae Herba and Saposhnikoviae Radix in treatment of ulcerative colitis].
Identifieur interne : 000243 ( Main/Exploration ); précédent : 000242; suivant : 000244[Network pharmacological study of Schizonepetae Herba and Saposhnikoviae Radix in treatment of ulcerative colitis].
Auteurs : Ying Qu [République populaire de Chine] ; Shu-Xin Zhang [République populaire de Chine] ; Lu Zhou [République populaire de Chine] ; Li-Yuan Fu [République populaire de Chine] ; Zi-Hao Liu [République populaire de Chine] ; Shi-Ying Li [République populaire de Chine] ; Ting-Ting Dai [République populaire de Chine] ; Xiang-Yang Yang [République populaire de Chine] ; Hui-Ru Ji [République populaire de Chine] ; Min-Ran Cao [République populaire de Chine]Source :
- Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica [ 1001-5302 ] ; 2019.
Descripteurs français
- KwdFr :
- Animaux (MeSH), Apiaceae (composition chimique), Bases de données génétiques (MeSH), Cartographie d'interactions entre protéines (MeSH), Humains (MeSH), Interleukines (métabolisme), Lamiaceae (composition chimique), Logiciel (MeSH), Médecine traditionnelle chinoise (MeSH), Médicaments issus de plantes chinoises (usage thérapeutique), Phytothérapie (MeSH), Racines de plante (composition chimique), Rectocolite hémorragique (traitement médicamenteux), Récepteurs de type Toll (métabolisme), Transduction du signal (MeSH).
- MESH :
- composition chimique : Apiaceae, Lamiaceae, Racines de plante.
- métabolisme : Interleukines, Récepteurs de type Toll.
- traitement médicamenteux : Rectocolite hémorragique.
- usage thérapeutique : Médicaments issus de plantes chinoises.
- Animaux, Bases de données génétiques, Cartographie d'interactions entre protéines, Humains, Logiciel, Médecine traditionnelle chinoise, Phytothérapie, Transduction du signal.
English descriptors
- KwdEn :
- Animals (MeSH), Apiaceae (chemistry), Colitis, Ulcerative (drug therapy), Databases, Genetic (MeSH), Drugs, Chinese Herbal (therapeutic use), Humans (MeSH), Interleukins (metabolism), Lamiaceae (chemistry), Medicine, Chinese Traditional (MeSH), Phytotherapy (MeSH), Plant Roots (chemistry), Protein Interaction Mapping (MeSH), Signal Transduction (MeSH), Software (MeSH), Toll-Like Receptors (metabolism).
- MESH :
- chemical , metabolism : Interleukins, Toll-Like Receptors.
- chemical , therapeutic use : Drugs, Chinese Herbal.
- chemistry : Apiaceae, Lamiaceae, Plant Roots.
- drug therapy : Colitis, Ulcerative.
- Animals, Databases, Genetic, Humans, Medicine, Chinese Traditional, Phytotherapy, Protein Interaction Mapping, Signal Transduction, Software.
Abstract
The aim of this paper was to screen the active targets of Schizonepetae Herba and Saposhnikoviae Radix in the treatment of ulcerative colitis by means of network pharmacology,and to investigate their mechanism of action. The effective components of Schizonepetae Herba and Saposhnikoviae Radix were screened out by traditional Chinese medicine systematic pharmacological( TCMSP)database,with oral bioavilability( OB) ≥30% and drug-like( DL) ≥18% selected as the thresholds. Target PPI network was built between the main components and their corresponding targets. One hundred and eighty-two human genes corresponding to the medicine target sites were obtained from Uniprot database; 3 874 genes corresponding to ulcerative colitis were obtained from Genecard database.A total of 115 intersection genes were screened from disease genes and medicine genes,and the PPI interaction analysis was conducted by using String tool. Disease-target PPI network was drawn by using Cytoscape software,and component-target-disease network was constructed. One hundred and eight nodes and 1 882 connections were found,and then Cytoscape software was used to merge the networks and filter the core network for gene GO function analysis and KEGG pathway enrichment analysis. The mechanism of Schizonepetae Herba and Saposhnikoviae Radix was then verified by animal experiment. Gene GO functional analysis suggested that biological process,molecular functions and cell components were involved,and it was found that ulcerative colitis might be related to transcription factor activity,and cytokine receptor binding,etc. Gene KEGG pathway enrichment analysis showed that the mechanism of ulcerative colitis might be associated with TNF and Toll-like receptors( TLRs) signaling pathway-mediated cytoinflammatory factors interleukin-1( IL-1) and interleukin-6( IL6). The possible mechanism of the effective components of Schizonepetae Herba and Saposhnikoviae Radix in treating ulcerative colitis might be related to intervening the cytokine receptor binding of TNF and TLRs signaling pathways,reducing the transcription of nuclear factor-kappaB( NF-κB),and inhibiting the secretion of intestinal inflammatory factors IL-1 and IL-6.
DOI: 10.19540/j.cnki.cjcmm.20190929.402
PubMed: 32237396
Affiliations:
Links toward previous steps (curation, corpus...)
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Traditional Chinese Medicine Beijing 100029,China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing University of Traditional Chinese Medicine Beijing 100029</wicri:regionArea></affiliation></author><author><name sortKey="Zhou, Lu" sort="Zhou, Lu" uniqKey="Zhou L" first="Lu" last="Zhou">Lu Zhou</name><affiliation wicri:level="1"><nlm:affiliation>Beijing University of Traditional Chinese Medicine Beijing 100029,China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing University of Traditional Chinese Medicine Beijing 100029</wicri:regionArea></affiliation></author><author><name sortKey="Fu, Li Yuan" sort="Fu, Li Yuan" uniqKey="Fu L" first="Li-Yuan" last="Fu">Li-Yuan Fu</name><affiliation wicri:level="1"><nlm:affiliation>Beijing University of Traditional Chinese Medicine Beijing 100029,China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing University of Traditional Chinese Medicine Beijing 100029</wicri:regionArea></affiliation></author><author><name sortKey="Liu, Zi Hao" sort="Liu, Zi Hao" uniqKey="Liu Z" first="Zi-Hao" last="Liu">Zi-Hao Liu</name><affiliation wicri:level="1"><nlm:affiliation>Beijing University of Traditional Chinese Medicine Beijing 100029,China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing University of Traditional Chinese Medicine Beijing 100029</wicri:regionArea></affiliation></author><author><name sortKey="Li, Shi Ying" sort="Li, Shi Ying" uniqKey="Li S" first="Shi-Ying" last="Li">Shi-Ying Li</name><affiliation wicri:level="1"><nlm:affiliation>Beijing University of Traditional Chinese Medicine Beijing 100029,China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing University of Traditional Chinese Medicine Beijing 100029</wicri:regionArea></affiliation></author><author><name sortKey="Dai, Ting Ting" sort="Dai, Ting Ting" uniqKey="Dai T" first="Ting-Ting" last="Dai">Ting-Ting Dai</name><affiliation wicri:level="1"><nlm:affiliation>Beijing University of Traditional Chinese Medicine Beijing 100029,China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing University of Traditional Chinese Medicine Beijing 100029</wicri:regionArea></affiliation></author><author><name sortKey="Yang, Xiang Yang" sort="Yang, Xiang Yang" uniqKey="Yang X" first="Xiang-Yang" last="Yang">Xiang-Yang Yang</name><affiliation wicri:level="1"><nlm:affiliation>Beijing University of Traditional Chinese Medicine Beijing 100029,China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing University of Traditional Chinese Medicine Beijing 100029</wicri:regionArea></affiliation></author><author><name sortKey="Ji, Hui Ru" sort="Ji, Hui Ru" uniqKey="Ji H" first="Hui-Ru" last="Ji">Hui-Ru Ji</name><affiliation wicri:level="1"><nlm:affiliation>Beijing University of Traditional Chinese Medicine Beijing 100029,China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing University of Traditional Chinese Medicine Beijing 100029</wicri:regionArea></affiliation></author><author><name sortKey="Cao, Min Ran" sort="Cao, Min Ran" uniqKey="Cao M" first="Min-Ran" last="Cao">Min-Ran Cao</name><affiliation wicri:level="1"><nlm:affiliation>Beijing University of Traditional Chinese Medicine Beijing 100029,China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing University of Traditional Chinese Medicine Beijing 100029</wicri:regionArea></affiliation></author></analytic><series><title level="j">Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica</title><idno type="ISSN">1001-5302</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals (MeSH)</term><term>Apiaceae (chemistry)</term><term>Colitis, Ulcerative (drug therapy)</term><term>Databases, Genetic (MeSH)</term><term>Drugs, Chinese Herbal (therapeutic use)</term><term>Humans (MeSH)</term><term>Interleukins (metabolism)</term><term>Lamiaceae (chemistry)</term><term>Medicine, Chinese Traditional (MeSH)</term><term>Phytotherapy (MeSH)</term><term>Plant Roots (chemistry)</term><term>Protein Interaction Mapping (MeSH)</term><term>Signal Transduction (MeSH)</term><term>Software (MeSH)</term><term>Toll-Like Receptors (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux (MeSH)</term><term>Apiaceae (composition chimique)</term><term>Bases de données génétiques (MeSH)</term><term>Cartographie d'interactions entre protéines (MeSH)</term><term>Humains (MeSH)</term><term>Interleukines (métabolisme)</term><term>Lamiaceae (composition chimique)</term><term>Logiciel (MeSH)</term><term>Médecine traditionnelle chinoise (MeSH)</term><term>Médicaments issus de plantes chinoises (usage thérapeutique)</term><term>Phytothérapie (MeSH)</term><term>Racines de plante (composition chimique)</term><term>Rectocolite hémorragique (traitement médicamenteux)</term><term>Récepteurs de type Toll (métabolisme)</term><term>Transduction du signal (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Interleukins</term><term>Toll-Like Receptors</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Drugs, Chinese Herbal</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Apiaceae</term><term>Lamiaceae</term><term>Plant Roots</term></keywords><keywords scheme="MESH" qualifier="composition chimique" xml:lang="fr"><term>Apiaceae</term><term>Lamiaceae</term><term>Racines de plante</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Colitis, Ulcerative</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Interleukines</term><term>Récepteurs de type Toll</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Rectocolite hémorragique</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Médicaments issus de plantes chinoises</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Databases, Genetic</term><term>Humans</term><term>Medicine, Chinese Traditional</term><term>Phytotherapy</term><term>Protein Interaction Mapping</term><term>Signal Transduction</term><term>Software</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Bases de données génétiques</term><term>Cartographie d'interactions entre protéines</term><term>Humains</term><term>Logiciel</term><term>Médecine traditionnelle chinoise</term><term>Phytothérapie</term><term>Transduction du signal</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The aim of this paper was to screen the active targets of Schizonepetae Herba and Saposhnikoviae Radix in the treatment of ulcerative colitis by means of network pharmacology,and to investigate their mechanism of action. The effective components of Schizonepetae Herba and Saposhnikoviae Radix were screened out by traditional Chinese medicine systematic pharmacological( TCMSP)database,with oral bioavilability( OB) ≥30% and drug-like( DL) ≥18% selected as the thresholds. Target PPI network was built between the main components and their corresponding targets. One hundred and eighty-two human genes corresponding to the medicine target sites were obtained from Uniprot database; 3 874 genes corresponding to ulcerative colitis were obtained from Genecard database.A total of 115 intersection genes were screened from disease genes and medicine genes,and the PPI interaction analysis was conducted by using String tool. Disease-target PPI network was drawn by using Cytoscape software,and component-target-disease network was constructed. One hundred and eight nodes and 1 882 connections were found,and then Cytoscape software was used to merge the networks and filter the core network for gene GO function analysis and KEGG pathway enrichment analysis. The mechanism of Schizonepetae Herba and Saposhnikoviae Radix was then verified by animal experiment. Gene GO functional analysis suggested that biological process,molecular functions and cell components were involved,and it was found that ulcerative colitis might be related to transcription factor activity,and cytokine receptor binding,etc. Gene KEGG pathway enrichment analysis showed that the mechanism of ulcerative colitis might be associated with TNF and Toll-like receptors( TLRs) signaling pathway-mediated cytoinflammatory factors interleukin-1( IL-1) and interleukin-6( IL6). The possible mechanism of the effective components of Schizonepetae Herba and Saposhnikoviae Radix in treating ulcerative colitis might be related to intervening the cytokine receptor binding of TNF and TLRs signaling pathways,reducing the transcription of nuclear factor-kappaB( NF-κB),and inhibiting the secretion of intestinal inflammatory factors IL-1 and IL-6.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" IndexingMethod="Curated" Owner="NLM"><PMID Version="1">32237396</PMID><DateCompleted><Year>2020</Year><Month>05</Month><Day>05</Day></DateCompleted><DateRevised><Year>2020</Year><Month>05</Month><Day>05</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">1001-5302</ISSN><JournalIssue CitedMedium="Print"><Volume>44</Volume><Issue>24</Issue><PubDate><Year>2019</Year><Month>Dec</Month></PubDate></JournalIssue><Title>Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica</Title><ISOAbbreviation>Zhongguo Zhong Yao Za Zhi</ISOAbbreviation></Journal><ArticleTitle>[Network pharmacological study of Schizonepetae Herba and Saposhnikoviae Radix in treatment of ulcerative colitis].</ArticleTitle><Pagination><MedlinePgn>5465-5472</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.19540/j.cnki.cjcmm.20190929.402</ELocationID><Abstract><AbstractText>The aim of this paper was to screen the active targets of Schizonepetae Herba and Saposhnikoviae Radix in the treatment of ulcerative colitis by means of network pharmacology,and to investigate their mechanism of action. The effective components of Schizonepetae Herba and Saposhnikoviae Radix were screened out by traditional Chinese medicine systematic pharmacological( TCMSP)database,with oral bioavilability( OB) ≥30% and drug-like( DL) ≥18% selected as the thresholds. Target PPI network was built between the main components and their corresponding targets. One hundred and eighty-two human genes corresponding to the medicine target sites were obtained from Uniprot database; 3 874 genes corresponding to ulcerative colitis were obtained from Genecard database.A total of 115 intersection genes were screened from disease genes and medicine genes,and the PPI interaction analysis was conducted by using String tool. Disease-target PPI network was drawn by using Cytoscape software,and component-target-disease network was constructed. One hundred and eight nodes and 1 882 connections were found,and then Cytoscape software was used to merge the networks and filter the core network for gene GO function analysis and KEGG pathway enrichment analysis. The mechanism of Schizonepetae Herba and Saposhnikoviae Radix was then verified by animal experiment. Gene GO functional analysis suggested that biological process,molecular functions and cell components were involved,and it was found that ulcerative colitis might be related to transcription factor activity,and cytokine receptor binding,etc. Gene KEGG pathway enrichment analysis showed that the mechanism of ulcerative colitis might be associated with TNF and Toll-like receptors( TLRs) signaling pathway-mediated cytoinflammatory factors interleukin-1( IL-1) and interleukin-6( IL6). The possible mechanism of the effective components of Schizonepetae Herba and Saposhnikoviae Radix in treating ulcerative colitis might be related to intervening the cytokine receptor binding of TNF and TLRs signaling pathways,reducing the transcription of nuclear factor-kappaB( NF-κB),and inhibiting the secretion of intestinal inflammatory factors IL-1 and IL-6.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Qu</LastName><ForeName>Ying</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Beijing University of Traditional Chinese Medicine Beijing 100029,China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Shu-Xin</ForeName><Initials>SX</Initials><AffiliationInfo><Affiliation>Beijing University of Traditional Chinese Medicine Beijing 100029,China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhou</LastName><ForeName>Lu</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Beijing University of Traditional Chinese Medicine Beijing 100029,China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fu</LastName><ForeName>Li-Yuan</ForeName><Initials>LY</Initials><AffiliationInfo><Affiliation>Beijing University of Traditional Chinese Medicine Beijing 100029,China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Zi-Hao</ForeName><Initials>ZH</Initials><AffiliationInfo><Affiliation>Beijing University of Traditional Chinese Medicine Beijing 100029,China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Shi-Ying</ForeName><Initials>SY</Initials><AffiliationInfo><Affiliation>Beijing University of Traditional Chinese Medicine Beijing 100029,China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dai</LastName><ForeName>Ting-Ting</ForeName><Initials>TT</Initials><AffiliationInfo><Affiliation>Beijing University of Traditional Chinese Medicine Beijing 100029,China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yang</LastName><ForeName>Xiang-Yang</ForeName><Initials>XY</Initials><AffiliationInfo><Affiliation>Beijing University of Traditional Chinese Medicine Beijing 100029,China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ji</LastName><ForeName>Hui-Ru</ForeName><Initials>HR</Initials><AffiliationInfo><Affiliation>Beijing University of Traditional Chinese Medicine Beijing 100029,China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cao</LastName><ForeName>Min-Ran</ForeName><Initials>MR</Initials><AffiliationInfo><Affiliation>Beijing University of Traditional Chinese Medicine Beijing 100029,China.</Affiliation></AffiliationInfo></Author></AuthorList><Language>chi</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>China</Country><MedlineTA>Zhongguo Zhong Yao Za Zhi</MedlineTA><NlmUniqueID>8913656</NlmUniqueID><ISSNLinking>1001-5302</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D004365">Drugs, Chinese Herbal</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007378">Interleukins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D051193">Toll-Like Receptors</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019661" MajorTopicYN="N">Apiaceae</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003093" MajorTopicYN="N">Colitis, Ulcerative</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D030541" MajorTopicYN="N">Databases, Genetic</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004365" MajorTopicYN="N">Drugs, Chinese Herbal</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007378" MajorTopicYN="N">Interleukins</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D019686" MajorTopicYN="N">Lamiaceae</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008516" MajorTopicYN="N">Medicine, Chinese Traditional</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008517" MajorTopicYN="N">Phytotherapy</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018517" MajorTopicYN="N">Plant Roots</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D025941" MajorTopicYN="Y">Protein Interaction Mapping</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015398" MajorTopicYN="N">Signal Transduction</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012984" MajorTopicYN="N">Software</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D051193" MajorTopicYN="N">Toll-Like Receptors</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Schizonepetae Herba-Saposhnikoviae Radix</Keyword><Keyword MajorTopicYN="N">network pharmacology</Keyword><Keyword MajorTopicYN="N">nuclear factor-kappa B(NF-kappa B)</Keyword><Keyword MajorTopicYN="N">ulcerative colitis</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>4</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>4</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>5</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32237396</ArticleId><ArticleId IdType="doi">10.19540/j.cnki.cjcmm.20190929.402</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Qu, Ying" sort="Qu, Ying" uniqKey="Qu Y" first="Ying" last="Qu">Ying Qu</name></noRegion><name sortKey="Cao, Min Ran" sort="Cao, Min Ran" uniqKey="Cao M" first="Min-Ran" last="Cao">Min-Ran Cao</name><name sortKey="Dai, Ting Ting" sort="Dai, Ting Ting" uniqKey="Dai T" first="Ting-Ting" last="Dai">Ting-Ting Dai</name><name sortKey="Fu, Li Yuan" sort="Fu, Li Yuan" uniqKey="Fu L" first="Li-Yuan" last="Fu">Li-Yuan Fu</name><name sortKey="Ji, Hui Ru" sort="Ji, Hui Ru" uniqKey="Ji H" first="Hui-Ru" last="Ji">Hui-Ru Ji</name><name sortKey="Li, Shi Ying" sort="Li, Shi Ying" uniqKey="Li S" first="Shi-Ying" last="Li">Shi-Ying Li</name><name sortKey="Liu, Zi Hao" sort="Liu, Zi Hao" uniqKey="Liu Z" first="Zi-Hao" last="Liu">Zi-Hao Liu</name><name sortKey="Yang, Xiang Yang" sort="Yang, Xiang Yang" uniqKey="Yang X" first="Xiang-Yang" last="Yang">Xiang-Yang Yang</name><name sortKey="Zhang, Shu Xin" sort="Zhang, Shu Xin" uniqKey="Zhang S" first="Shu-Xin" last="Zhang">Shu-Xin Zhang</name><name sortKey="Zhou, Lu" sort="Zhou, Lu" uniqKey="Zhou L" first="Lu" last="Zhou">Lu Zhou</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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